If you have started playing Once Human’s new PvP Scenario, “Prismverse’s Clash,” whether you choose to be on the Mayflies or Rosetta’s factions, there are entirely new Memetic Specializations. To ensure you select the right Memetics Specialization, I have prepared this detailed guide sharing Once Human Prismverse’s Clash all new Memetic Specializations and what they do.
You learn about the new Memetic Specializations when you are in the faction selection screen that details that choosing Rosetta will give you access to drones, whereas choosing Mayflies will give you access to Gene Extractor and Gene Coherence Injection for buffs and special abilities.
Irrespective of which faction you go with, the new Memetics Specialization associated with both under the banner of Legendary Maylfies and Legendary Rosetta, all the new ones are available to you on a random roll basis as seen in previous Scenario and Seasons.
Deciding which Metic Specialization to choose can be difficult if you don’t have a good overview of all the new ones.
So, keep reading as I list all the new Memetic Specializations in Once Human Prismverse’s Clash and what they do.
Once Human Prismverse’s Clash Legendary Mayflies Memetic Specialization

There are twelve new Memetic Specialization that come under the Legendary Mayflies path in Once Human:
| Memetic Specialization | What do they do? | When do they appear? |
| Nature Coherence Injection | Unlock new formulas: Gene Extractor, Nature Coherence Injection When holding the Gene Extractor, defeating Deviants yields gene fragments based on enemy types. These fragments can be used to craft the Gene Coherence Injection for enhancing gathering abilities. The Coherence status ends after taking damage equal to 70% of your Max HP. After using the Nature Coherence Injection, each gathering action grants 1 Coherence, with the following effects based on the materials used. Deviant Fragment: At 10 Coherence, Mining Savage Strike Rate +50%, and Mining Last Hit Yield +100%. Anima Fragment: At 10 Coherence, while holding a pickaxe or chainsaw, Movement Speed +15%, and the yield of Logs, Sulfur, Silver Ore, Gold Ore, and Stardust +30%. Starlith: At 30 Coherence, consume all Coherence to increase final hit yield from logging and mining by 1,000% for 5s. Matterlith: At 30 Coherence, there’s a small chance to trigger an Oil Gusher when mining in contested areas, granting 30 Barreled Crude Oil to all allied players within 5 meters. | Level 5 |
| Judgment Coherence Injection | Unlock new formulas: Gene Extractor, Judgement Coherence Injection When holding the Gene Extractor, defeating Deviants yields gene fragments based on enemy types. These fragments can be used to craft the Gene Coherence Injection for enhancing crafting abilities. The Coherence status ends after taking damage equal to 70% of your Max HP. After using the Judgement Coherence Injection, each enemy defeated grants 1 Coherence, with the following effects based on the materials used. Deviant Fragment: At 10 Coherence, Status DMG +10%. Anima Fragment: At 10 Coherence, Weapon DMG +10%. Starlith: At 30 Coherence, enter Beyond Mode, consuming 1 Coherence per attack, dealing 50 Sanity DMG to players, and DMG equal to 10% of Max HP to non-player enemies (up to 5,000). Exit Beyond Mode when Coherence is depleted. Matterlith: At 30 Coherence, Roll Stamina Consumption +50%, Roll Speed +30%, DMG Reduction during rolling increased to 80%, and summon a Flamethrower Trap that deals damage equal to 1,000% Psi Intensity over 5s. | Level 5 |
| Speed Coherence Injection | Unlock new formulas: Gene Extractor, Speed Coherence Injection When holding the Gene Extractor, defeating Deviants yields gene fragments based on enemy types. These fragments can be used to craft the Gene Coherence Injection for enhancing mobility. The Coherence status ends after taking damage equal to 70% of your Max HP. After using the Nature Coherence Injection, moving for 2s grants 1 Coherence, with the following effects based on the materials used: Deviant Fragment: At 10 Coherence, enhance V’s abilities, reducing Gliding Speed by 70% and increasing horizontal Gliding Speed by 50%. Anima Fragment: At 10 Coherence, recover 5% HP and Sanity per second while driving, and gain Shield equal to 60% of Max HP when exiting driving. (cooldown: 30s) Starlith: At 30 Coherence, gain invisibility for 10s after gliding ends. Matterlith: At 30 Coherence, while in a mobile territory or vehicle, Weapon DMG +20%, Status DMG +20%, and DMG Reduction +20%. | Level 5 |
| Elysium Coherence Injection | Unlock new formulas: Gene Extractor, Elysium Coherence Injection When holding the Gene Extractor, defeating Deviants yields gene fragments based on enemy types. These fragments can be used to craft the Gene Coherence Injection for enhancing both defensive and offensive abilities. The Coherence status ends after taking damage equal to 70% of your Max HP. After using the Elysium Coherence Injection, staying in any territory for 3s will grant you 1 Coherence, with the following effects based on the materials used: Deviant Fragment: At 10 Coherence, unlock Double Jump and Aerial Sprint abilities within your territory. Anima Fragment: At 10 Coherence, Attack of all allied turrets and traps within the territory +50%. Starlith: At 30 Coherence, convert all Coherence to Ascension, increasing Psi Intensity by 1% per stack but reducing Attack by 0.5%. Each attack consumes one stack of Ascension. Matterlith: At 30 Coherence, while in the territory, Stamina Consumption -30%, Roll Speed +30%, and Tactical Item DMG +30%. | Level 5 |
| Proliferation Gene | Unlock new formulas: Proliferation Gene. A special item to enhance the Gene Coherence and unlock its advanced capabilities. After using the injection, create a Proliferation Zone. Within this zone, the acquisition amount for all Parts, Fabrics, Plastics, Metal Scraps, Rubber, Adhesives, Electronic Parts, Crystals, and Acid is increased by 30% for 10s. | Level 20 |
| Extreme Gene | Unlock new formulas: Extreme Gene. A special item to enhance the Gene Coherence and unlock its advanced capabilities. The Coherence status termination condition changes to total damage taken reaching 150% of Max HP. When HP is below 50%, Max Load +50. When HP is below 30%, Weapon DMG +15%, Tactical Item DMG +15%. When HP is below 10%, trigger a healing effect, recovering 1% of Max HP for each unused point of Max Load(20s cooldown) | Level 20 |
| Lightning Gene | Unlock new formulas: Lightning Gene. A special item to enhance the Gene Coherence and unlock its advanced capabilities. In combat, automatically select a random enemy within 20 meters every 10s, generating a lightning strike beneath them after a 3s delay, dealing damage equal to 4,000% Psi Intensity. | Level 20 |
| Bastille Gene | Unlock new formula: Extreme Gene Fabric Used when making equipment, the equipment will gain the following effects: Weakness damage reduction +3% If this equipment is a top, additional effect is obtained: When the Synchronization State is released, the invincibility effect is obtained, Weapon Damage, Sanity DMG and Tactical Item damage are reduced to 0, which lasts for 2s. | Level 20 |
| Proliferation Gene Fabric | Unlock new recipe: Proliferation Gene Fabric Used when making equipment, the equipment will gain the following effects: Carrying capacity +10 If this equipment is a top, additional effect is obtained: When in the synchronization state, a small amount of barrels of crude oil in the backpack is converted into portable mixed fuel every 30 seconds. | Level 40 |
| Extreme Gene Fabric | Unlock new formula: Extreme Gene Fabric Used when making equipment, the equipment will gain the following effects: Weakness damage reduction +3% If this equipment is a top, additional effect is obtained: When the synchronization state is released, the invincibility effect is obtained, and the Weapon DMG, Sanity DMG, and Tactical Item DMG are reduced to 0, which lasts for 2s. | Level 40 |
| Lightning Gene Fabric | Unlock new recipe: Lightning Gene Fabric. Used when making equipment, the equipment will gain the following effects: Critical damage reduction +3% If this equipment is a top, additional effect is obtained: When in the synchronized state, when attacked, a lightning strike is generated at the attacker’s feet with a delay of 3 seconds, causing indiscriminate damage of 4000% Psi Intensity (cooldown 30s) | Level 40 |
| Bastille Gene Fabric | Unlock new recipe: Fortress Gene Fabric. Used when making equipment, the equipment will gain the following effects: Equipment durability +30% If this equipment is a top, additional effect is obtained: When in the synchronization state, 10 Stardust Essence will be automatically consumed every minute, restoring 10% durability of the lowest durability equipment worn. | Level 40 |
Once Human Prismverse’s Clash Legendary Rosetta Memetic Specialization

Similar to the Mayflies faction, the Legendary Rosetta offers twelve new Memetic Specializations based around Drones. These are:
| Memetic Specialization | What do they do? | When do you unlock them? |
| Rosetta Gathering Drone | Unlock new formula: Rosetta Gathering Drone. The Rosetta Gathering Drone can be summoned at any time. The drone will automatically search and collect the highest level of minerals around them, granted the player’s load has not reached the max limit. The special advanced effects depend on the crafting materials used. | Level 5 |
| Rosetta Firepower Drone | Unlock new formula: Rosetta Firepower Drone. The Rosetta Firepower Drone can be summoned at any time. The drone has mid-range shooting capabilities. The special advanced effects depend on the crafting materials used. | Level 5 |
| Rosetta Exploration Drone | Unlock new formula: Rosetta Exploration Drone. The Rosetta Exploration Drone can be summoned at any time. When the Exploration Drone is present, it can replace V to perform special gliding. Special Gliding has no take-off height limit and will not reduce altitude during gliding. But the Stamina consumption rate is greatly increased. The special advanced effects depend on the crafting materials used. | Level 5 |
| Rosetta Territory Drone | Unlock new formula: Rosetta Territory Drone. The Rosetta Territory Drone can be summoned at any time. When the player is in territory, the territory drone can unlock long-range shooting capabilities, and the attack power of all friendly turrets and traps in the territory will be increased by 50%. The special advanced effects depend on the crafting materials used. | Level 5 |
| Focus Module | Unlock new recipe: Focus Module Special items that can be used to strengthen the drone, unlocking advanced abilities. Collection drone: When the drone is mining in the contested zone, there is a chance to obtain 10-100 barrels of Crude Oil from the ground. Firepower Drone: Unstable bomber effect can be triggered when the drone attacks. Exploration Drone: Gliding stamina consumption is reduced by 50%. During gliding, a random enemy within 20m will be automatically marked every 4 seconds. Territory Drone: After the drone has accumulated 10 hits, it will provide 5% Weapon Damage and Sanity DMG bonus to all friendly players within 15m, which lasts for 10 seconds and can be stacked up to 3 times | Level 20 |
| Wide-Area Module | Unlock new recipe: Wide Area Module. Special items that can be used to strengthen the drone, unlocking advanced abilities. Collection Drone: The drone will double its output when collecting minerals, and will destroy all collected objects within a 3m range. Firepower drone: The ejection effect can be triggered when the drone attacks. Exploration drone: horizontal gliding speed is greatly increased, and 20% damage reduction is obtained during gliding. Territory Drone: When a drone is in a territory, it will automatically generate a spherical shield every 30 seconds, which can absorb 5000% of the drone’s attack damage. | Level 20 |
| Speedy Module | Unlock new recipe: Speed module. Special items that can be used to strengthen the drone, unlocking advanced abilities: Collection Drone: When the player holds a collection tool, the maximum endurance value is increased by 50 points, and the movement speed is increased by 20% and the sprint speed is increased by 30%. The final hit of the collection is increased by 200%. Firepower Drone: The drone unlocks the electric shock skill, which allows it to rush towards enemies within the attack range and paralyze them for 3 seconds. Exploration Drone: Players gain a 15% movement speed bonus and the ability to double jump. Territory Drone: When the player is in a territory other than his own, stamina consumption is reduced by 30%, rolling speed is increased by 30%, and tactical item damage is increased by 30% | Level 20 |
| Support Module | Unlock new recipe: Support module Special items that can be used to strengthen the drone, unlocking advanced abilities. Collection Drone: Converts part of the ore in the player’s backpack into corresponding metal ingots every 30 seconds (without consuming Fuel and Acid) Firepower drone: The drone has unlocked the healing skill. After using it, it will heal the friendly player with the lowest health in the range. If the player does not rise within 10 seconds after falling to the ground, the falling state will be released. Exploration drone: Player enters stealth mode after leaving combat. Territory Drone: When the player is in his own territory, he will recover 5% of his health per second. When his health is less than 50%, he will enter stealth mode. (cooldown 30s) | Level 20 |
| Invisible Module | Unlock new recipe: Stealth Module Special items can be used to strengthen the drone, unlocking advanced abilities. Automatically consumes 10 Stardust Essence, making the drone enter stealth mode for 6 minutes. The drone will exit stealth mode when it causes damage. | Level 40 |
| Armor Module | Unlock new recipe: Armor Module. Special items that can be used to strengthen the drone, unlocking advanced abilities. When the drone has no shield, it will automatically consume 3 electronic components every 30 seconds, allowing the drone to gain 6000 shield points. | Level 40 |
| Load Module | Unlock new recipe: Weight module. Special items that can be used to strengthen the drone, unlocking advanced abilities. Automatically consume S portable mixed fuels every 10 minutes, giving the player a 100-point load limit for 10 minutes. | Level 40 |
| Healing Module | Unlock new recipe: Self-healing module. Special items that can be used to strengthen the drone, unlocking advanced abilities. Every 10 minutes, 10 Adhesives, Metal Scraps, and 5 Rubbers are automatically consumed, restoring 50% durability of the lowest durability equipment. | Level 40 |
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Can you reset Rosetta or Mayflies Memetic Specializations in Once Human?

Yes. Like any other Memetic Specialization, you can reset your Legendary Mayfly and Legendary Rosetta Memetic Specializations in Once Human, granted you have the required item or Special Memory Fragments.
Are the new Prismverse’s Memetic Specializations faction locked?

No! As you can see, I chose the Mayfly faction and still got the Fire Drone Memetic Specialization as a random roll.
The only difference are the pre-defined Memetic Specialization you get at Level 5, 20 and 40.
If you are more into the Legendary Mayfly Memetic Specialization, instead of choosing Rosetta and waiting for random Mayfly Memetic Specialization rolls, you can just choose the Mayfly faction and vice versa.
Here’s a video I recorded when I got the new Memetic Specialization:
That concludes my guide on Once Human Prismverse’s Clash all new Memetic Specializations. If the article helped, please consider buying me a Coffee to help me create more content. You can also share the guide with your friends or leave a comment.
